Abstract
Abstract A seasonal variation was observed in the mitogenic response of human tonsillar lymphocytes and in the percentages of each subset. We found that the responsiveness of lymphocytes to mitogens was high in summer and low in winter. The identification of lymphocyte subsets by using monoclonal antibodies indicated that the percentages of T4 positive cells and T8 positive cells increased in summer and decreased in winter. The most significant change was observed in the percentages of T8 positive cells. The significant relationship between the mitogenesis and the percentages of T8 positive cells was observed. These results indicated that the seasonal variation in lymphocyte mitogenesis might depend on the size of T8 positive cells.
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