Abstract
RESULTS: Acute hepatic necrosis was detected in 3/4 rats examined from 2004 outbreak and in both rats from 2009 outbreak. Large, slender bacilli, typical of Clostridium piliforme were seen in Warthin-Starry silver stained sections. In 2009 cases C. piliforme DNA was found in formalin-fixed paraffin-embedded liver tissues by PCR. Sequencing of conserved region of C. piliforme showed that the strain was 99% homologous to mouse isolate. These findings support Tyzzer‟s disease as the cause for both outbreaks.
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