Seasonal occurrence of multiple classes of antibiotics in East China rivers and their association with suspended particulate matter

Abstract

Understanding the occurrence and fate of antibiotics from different categories is vital to predict their environmental exposure and risks. This study presents the spatiotemporal occurrence of 45 multi-class antibiotics and their associations with suspended particulate matter (SPM) in Xiaoqing River (XRB) and Yellow River (YRB) via 10-month monitoring in East China. Thirty-five and 31 antibiotics were detected in XRB and YRB, respectively. Among them, fluoroquinolones (FQs) had the highest total mean concentration (up to 24.8 μg/L in XRB and 15.4 μg/L in YRB), followed by sulfonamides (SAs) (14.0 μg/L and 15.4 μg/L) and macrolides (MLs) (1.1 μg/L and 1.6 μg/L). Significant spatial-temporal variations were found in both rivers where higher concentrations of antibiotics were observed in urban and densely populated areas during winter and spring. Hydrological factors such as river flow and water volume, instream attenuation and antibiotic usage may cause the observed variabilities in the seasonal patterns of antibiotic pollution. Using linear regression analysis, for the first time, this study confirmed that the total concentrations of MLs (p < 0.05), FQs (p < 0.001) and SAs (p < 0.001) were strongly correlated with the turbidity/total suspended solids in the studied rivers (except MLs in YRB). It is thus suggested that partitioning processes onto SPM might affect the distribution of detected antibiotics in rivers, which are largely dependent on SPM composition and characteristics. The risk quotient (RQ) determined for up to 87 % of individual compound was below 0.1 in both rivers; however, the high joint toxicity reflected by the mixed RQs of detected antibiotics may rise risk alarm for aquatic species. Further aspects regarding active mechanisms of SPM-antibiotic interactions and ecological risks of coexistence of multiple antibiotics need to be investigated.