Abstract
The results of a 5-year neonatal screening of thyrotropic hormone (TTH) in 51,222 neonatal infants were analyzed to evaluate the severity of goiter endemia in the Arkhangelsk Region that is an area of mild and moderate iodine deficiency and a high-latitude region. The analysis established the following regularity: the spread of elevated TTH levels > 5 m U/l in neonatal infants was much higher in summer months. The fluctuating pattern of transient hyperthyrotropinemia was found in the contrast seasons. The magnitude of these fluctuations depended on the climatic and geographic area where the infants had been bom. The seasonal contrast range of transient hyperthyrotropinemia and the increase in the severity of goiter endemia by this criterion in summer make it possible to analyze the results of neonatal TTH screening in June to August as a more precise indicator during monitoring the severity of goiter endemia and the effectiveness of iodine deficiency prevention in high-latitude regions where environmental factors make a substantial contribution to the functional activity of the pituitary-thyroid system.
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