Seasonal Changes of Body Iron Status Determine Cadmium Accumulation in the Wild Bank Voles

Abstract

The objective of this study was to examine relations between body iron (Fe) status and cadmium (Cd) accumulation in a small rodent, the bank vole, caught from the wild population in late autumn (November) and early spring (March). The concentrations of Fe in the liver, kidneys, and duodenum in the bank voles from the spring were only 30%, 60%, and 70%, respectively, of those found in the animals from the autumn. An analysis of hematocrit and hemoglobin content of blood showed no significant effect of the season, suggesting that the animals from the spring were not anemic. The exposure to dietary Cd (10 microg/g) for 7 days resulted in 70% higher accumulation of Cd in the liver and kidneys of the spring than autumn bank voles, and the concentration of Cd in the duodenum was 3.5 times higher in the spring animals, despite the fact that relative Cd intake was significantly higher in the autumn bank voles. The data indicate that seasonal changes of body Fe status occurring in the wild bank voles may influence tissue accumulation of Cd.