Abstract
SUMMARY In the present study, the ethanolic leaf and bark extract of Wrightia tomentosa were tested forcomparative in vivo antitumour properties against Ehrlich ascites carcinoma (EAC) tumourbearing mice at 100 and 200 mg/kg body weight doses given orally once daily for 16 days. TheEAC mice receiving 100 and 200 mg/kg ethanolic leaf and bark extract showed a dose dependentelevation in tumour – free survival and a highest number of survivors were observed at 200 mg/kg for leaf extract of ethanol, which was considered as an optimum dose for its anti neoplasticaction. The Median survival time for this dose was approximately 44 days when compared with23 days of non-drug treated controls. The results indicate that the administration of leaf extractnot only increased the survival of animals with ascites tumour and reduced packed cell volumeand viable tissue cell count, but also altered many hematological parameters changed duringtumour progression, indicating the potent antitumour nature of leaf extract than the bark extract.Statistical analysis also reveals that the leaf extract showed highly significant anti tumour potency(p < 0.001) when compared with control.Key words: Wrightia tomentosa; Ethanol extract; Leaf, Bark; Ehrlich ascites carcinoma (EAC);antitumour
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