Abstract
Chronic inflammation is often accompanied by the formation of ectopic lymphoid tissue, including infiltrations of T lymphocytes and B lymphocytes, and formation of follicular structures around a network of follicular dendritic cells (FDCs). Ectopic follicular structures may serve as survival niches for undesirable B-cell clones, and FDCs provide powerful survival signals to B lymphocytes [1]. There is broad consensus that FDCs show phenotypic overlap with fibroblasts and are of mesenchymal origin, but the formation of FDCs is poorly understood and a FDC-precursor cell has not been identified [2]. It has been shown in mice that the expression of members of the tumor necrosis factor receptor family, especially of the receptor for lymphotoxin-beta (LTβR), on FDC precursors is a condition for FDC maturation.
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