Abstract
The specimens of 111 cervical carcinomas, 68 chronic cervicitis and 43 normal cervical exfoliated epithelial cells were examined for the presence of HSV-2 DNA sequences with DNA hybridization using HSV-2 BgL I N fragment probe labelled by 32P-dCTP. The result showed that the infection rates of HSV-2 in the samples of cervical cancer, chronic cervicitis and normal epithelial cells were 14.41% (16/111), 27.94% (19/68) and 25.58% (11/43), respectively. It was implied that early stages carcinogenesis of cervical epithelial cells might be correlated with the HSV-2 infection. Sixteen HSV- 2 positive samples of cervical carcinomas were also examined for the presence of the sequences homologous to human papillomavirus (HPV) type 6B/11, 16 and 18 DNA using dot blot hybridization (Tm-17C). The result indicated that 13 out of 16 were HPV 16 DNA hybridization positive accounting for 81.2% of all HSV-2 positive samples and none of them were positive for HPV type 6B/11 and 18. The result indicated that double infection of HSV-2 and HPV16 in the same cervical carcinoma tissues may provide a strong evidence of the viral synergistic interaction in the induction of female cervical carcinomas.
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