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Abstract
Background: The skin is the outer shell of the mammalian body and it is continuously exposed to a large spectrum of external stimuli including sun irradiation and atmospheric pollutants. These factors present deleterious effects on the cutaneous compartment by altering the skin barrier functions and accelerating the aging of the skin. Objectives: The goal of this study was to investigate the activity of Seaberry and Water Lily extracts, here called Dermina complex, against different external stresses. Methods: Human skin explants were exposed to different stimuli including delipidation by organic solvents, blue light, atmospheric pollutants and UV-A. The activity of the Seaberry and Water Lily extracts was assessed by immunohistochemistry and by biochemical assays. Results: We showed that Dermina complex prevents the delipidation-induced filaggrin decrease, suggesting that these plant extracts exhibited barrier function protecting properties. Also, we observed that Dermina complex showed an antioxidant and DNA protection activity by decreasing the activated form of Nrf2, the oxidized proteins and the formation of γ-H2AX induced upon stress conditions. The Dermina complex also decreased the pro-inflammatory cytokine IL-1 alpha released in the culture medium following atmospheric pollutants and UV-A exposure confirming its anti-inflammatory activity. Moreover, Dermina complex reduced the blue light-induced overexpression of opsin 3, indicating that its skin protection activities may be due, in part, to filter property against environmental stresses. Conclusions: Dermina complex shows a protective activity of the skin against different environmental stresses and these extracts may be able to slow down the aging process of the cutaneous compartment.
Highlights
The human exposome is defined as the totality of stresses to which our body is exposed during its entire lifetime [1].Since the skin is the outermost organ of human body and interacts daily with the environment, the skin exposome affects significantly human well-being [2].If the effects of UV irradiations on the skin have been thoroughly analyzed so far the effects of air pollution on the skin have become a central subject of investigation of the worldwide scientific community more recently [3].Environmental pollution is nowadays considered as one of the most important factors that impact skin physiology and integrity, and the chronic exposure of skin to atmospheric pollutants can impair cutaneous homeostasis leading to skin barrier dysfunctions
In order to assess the capacity of the Dermina complex to reestablish proper barrier functions, the surface of human skin explants was treated with a mix of ether/acetone
The extracts increased significantly the expression of filaggrin by 76% compared to the delipidated explants (p < 0.05), almost restoring the filaggrin expression found in the control explants (Figure 1)
Summary
The human exposome is defined as the totality of stresses to which our body is exposed during its entire lifetime [1].Since the skin is the outermost organ of human body and interacts daily with the environment, the skin exposome affects significantly human well-being [2].If the effects of UV irradiations on the skin have been thoroughly analyzed so far the effects of air pollution on the skin have become a central subject of investigation of the worldwide scientific community more recently [3].Environmental pollution is nowadays considered as one of the most important factors that impact skin physiology and integrity, and the chronic exposure of skin to atmospheric pollutants can impair cutaneous homeostasis leading to skin barrier dysfunctions. The skin is the outer shell of the mammalian body and it is continuously exposed to a large spectrum of external stimuli including sun irradiation and atmospheric pollutants. These factors present deleterious effects on the cutaneous compartment by altering the skin barrier functions and accelerating the aging of the skin. Objectives: The goal of this study was to investigate the activity of Seaberry and Water Lily extracts, here called Dermina complex, against different external stresses. Methods: Human skin explants were exposed to different stimuli including delipidation by organic solvents, blue light, atmospheric pollutants and UV-A. Results: We showed that Dermina complex prevents the delipidation-induced filaggrin decrease, suggesting that these plant extracts exhibited barrier function protecting properties. Dermina complex reduced the blue light-induced overexpression of opsin 3, indicating that its skin protection activities may be due, in part, to filter property
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