Sea Buckthorn and Rosehip Oils with Chokeberry Extract to Prevent Hypercholesterolemia in Mice Caused by a High-Fat Diet In Vivo

Lubov Tereshchuk,Irina Sergeeva,Olga Babich,Svetlana Ivanova,Lyubov Dyshlyuk,Alexander Prosekov,Kseniya Starovoytova,Valery Pavsky

doi:10.3390/nu12102941

Lubov Tereshchuk, Irina Sergeeva + Show 6 more

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https://doi.org/10.3390/nu12102941

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Abstract

Dietary supplementation based on sea buckthorn and rosehip oils with added chokeberry extract was studied. We added the dietary supplement to the feed mixtures for laboratory animals. The possible toxicological effects and hypocholesterolemic, hepatoprotective activity of the dietary supplement in vivo were studied. After the observation period (6 weeks), no significant changes were found in the mass of organs and blood serum of laboratory animals (p > 0.05). However, there was a decrease in hypercholesterolemic indicators. Regular consumption of sea buckthorn and rosehip oils with added chokeberry extract (dietary supplement “ESB-1”) by laboratory animals inhibited the activity of liver enzymes and increased the antioxidant activity of blood serum (after the subcutaneous injection of sunflower oil/oil solution of carbon tetrachloride) but was not sufficient to bring them to physiological standards. The hypocholesterolemic and antioxidant properties of our dietary supplement already allow us to consider it a component of functional food products or a dietary supplement base. However, the full range of its biologically active properties, including the hepatoprotective function and regulation of metabolic disorders, has not been studied yet, which sets the direction of further research in vivo models and clinical practice to confirm its effectiveness in humans.

Highlights

In addition to oncological diseases, cardiovascular diseases, hepatitis, and diabetes are the main ones causing death or disability
The aim of the study was to evaluate the effect of sea buckthorn oil, rosehip oil, and chokeberry extract combined on the manifestation of hypercholesterolemia in mice due to the predominance of fat in the diet
We went further and developed a dietary supplement based on sea buckthorn and rosehip oil

Summary

Introduction

In addition to oncological diseases, cardiovascular diseases, hepatitis, and diabetes are the main ones causing death or disability. Such diseases can often be prevented by maintaining a healthy lifestyle and sticking to a healthy diet [1,2,3]. Plant food components with antioxidant properties, especially the ones with phenolic compounds, are of particular interest. Hepatoprotective, antiproliferative and anti-obesity effects of phenolic compounds have been reported [7,8,9]. A high content of polyunsaturated fatty acids (PUFA), mainly vegetable oil and nuts, is a key component of a healthy diet to prevent heart diseases [10,11]

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