Abstract
Selenium compounds have strong anti-tumor effects and are well-tolerated. We examined the anti-tumor effects of (NH4)2H15Se2VIMo10V3O52·2H2O (Se2Mo10V3), a heteropoly compound containing selenium. Se2Mo10V3 inhibited proliferation in K562 cells with a half-maximal inhibitory concentration of 78.72±2.82 mg/L after 48 h and 24.94±0.88 mg/L after 72 h. Typical apoptotic morphologies were also observed in K562 cells treated with Se2Mo10V3, as were increased intracellular levels of Ca2+, Mg2+, H+, and reactive oxygen species, and decreased mitochondrial membrane potential. In addition, Se2Mo10V3 treatment triggered cytochrome C release and inhibited IκBα degradation and NF-κB translocation. In vivo experiments revealed that 5 or 10 mg/kg Se2Mo10V3 inhibited the growth of sarcoma 180 and hepatoma 22 xenograft tumors. These results indicate that Se2Mo10V3 inhibits tumor growth both in vitro and in vivo and induces apoptosis in K562 cells, possibly by inhibiting the NF-κB/IκBα pathway.
Highlights
Selenium, an essential non-metal trace element [1], is crucial to the function of several enzymes, including glutathioneperoxidases and thioredoxin reductases [2]
Kg Se2Mo10V3 inhibited the growth of sarcoma 180 and hepatoma 22 xenograft tumors. These results indicate that Se2Mo10V3 inhibits tumor growth both in vitro and in vivo and induces apoptosis in K562 cells, possibly by inhibiting the NF-κB/IκBα pathway
We demonstrated that Se2Mo10V3, a heteropoly compound containing selenium, had anti-tumor effects both in vitro and in vivo
Summary
An essential non-metal trace element [1], is crucial to the function of several enzymes, including glutathioneperoxidases and thioredoxin reductases [2]. Selenium compounds can prevent tumor formation [5], mainly by inducing apoptosis [6]. Yang and Wang found that Na5SeV5O18.H20, a heteropoly compound containing selenium, had antitumor effects both in vitro and in vivo [7]. When used as therapeutic agents in tumor patients, selenium compounds are well-tolerated [8]. The possible anti-tumor effects and related underlying mechanisms for another selenium-containing heteropoly compound, (NH4)2H15Se2VIMo10V3O52·2H2O (abbreviation: Se2Mo10V3), have not yet been studied. We examined the anti-tumor effects of Se2Mo10V3 and the mechanisms underlying those effects
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