SDS–MoS2 nanoparticles as highly-efficient peroxidase mimetics for colorimetric detection of H2O2 and glucose

Abstract

In this work, we find that the peroxidase-like activity of MoS2 nanoparticles (NPs) is dependent on the surface charge. Negatively charged sodium dodecyl sulfate modified MoS2 nanoparticles (SDS–MoS2 NPs) possess highly-efficient peroxidase-like activity. MoS2 NPs with intrinsic peroxidase-like activity were synthesized through a simple one-pot hydrothermal route. The peroxidase-like activities of different surfactants modified MoS2 NPs were discussed. Compared with bare MoS2 NPs and positively charged cetyltrimethyl ammonium bromide modified MoS2 NPs, SDS–MoS2 NPs have the best peroxidase-like activity. SDS–MoS2 NPs can efficiently catalyze the oxidation of 3,3,5,5-tetramethylbenzidine (TMB) in the presence of H2O2 to generate a blue product. On basis of this, we have successfully established a novel platform for colorimetric detection of H2O2, and the detection limit is 0.32μM. Furthermore, the SDS–MoS2 NPs based platform can also be used for high sensitivity and selectivity detection of glucose with a wide linear range of 5.0–500μM by controlling the generation of H2O2 in the presence of glucose oxidase.