Abstract
Both periodontal ligament tissue that located between the alveolar bone and the root of teeth and dental pulp tissue are reported to have mesenchymal stem cells [1, 2] (MSCs). MSCs are considered to be involved in the homeostasis of periodontal tissue. Recent studies have revealed that the stromal cell-derived factor-1α (SDF-1) is crucial for migration of endothelial precursor cells and MSCs through its receptor, CXCR4. However, regulation of SDF-1 expression in the periodontal ligament cells is still unknown. In this study, we investigated whether FGF-2 could regulate the expression of SDF-1 in periodontal ligament cells derived from human permanent teeth.
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