SD OCT and fundus auto fluorescence findings in Stargardt disease

Abstract

AbstractPurpose To analyze macular morphology with SD OCT and Fundus Auto Fluorescence (FAF) in patients with Stargardt disease (STGD) and to correlate between visual acuity (VA) and macular patterns.Methods Forty eyes with STGD phenotypes, underwent FAF and SD‐OCT imaging. The levels and the distribution of FAF and atrophic lesions were evaluated.Results Patients were separated in 2 groups: BCVA ≥ 0.05 and BCVA< 0.05.We found 5 patterns in FAF: Homogeneous high AF of the entire retina; Heterogeneous high and low retinal AF with low central AF; Numerous small areas of atrophy in heterogeneous low AF; Large an isolated central retinal atrophy; Central retinal atrophy without foveolar involvement. Six patterns were found in SD‐OCT: Normal foveal depression, regular photoreceptor IS/OS junction with hyper reflectivity of outer nuclear layer; subnormal foveal depression, foveal disorganization and/or loss of IS/OS junction; Absence of foveal depression, loss of the IS/OS junction and the photoreceptors layer; Macular hole aspect; large retinal atrophy with macular layers disorganization; Pseudo‐coloboma image. Foveal thickness was significantly reduced in all patients (Mean = 107.92 µm) excepted in group I with subclinical STGD. There was a statistically significant correlation between FAF pattern and SD‐OCT pattern (p=0.03) and between BCVA and SD‐OCT pattern (p=0.04).Conclusion Both SD‐OCT and FAF are useful in the management of STGD. Correlation between structure and function should be useful in guiding selection of patients for future therapeutic.