Abstract
See article by Tu et al. [6] (pages 486–495) in this issue. Platelets represent an important link between inflammation, thrombosis, and vascular and tissue repair mechanisms. Once activated, platelets generate and release an arsenal of potent inflammatory, proliferative, and mitogenic substances into the local microenvironment of vascular lesions [1]. Thereby, platelets control and effect multiple mechanisms of cellular function involved in vascular and tissue repair. The epidermal growth factor (EGF) superfamily is a group of growth factors, cytokine-like mediators, and extracellular matrix proteins. A new gene of an EGF-related protein was isolated 6 years ago in developing mice [2]. This new mammalian gene encodes a protein with a signal peptide at the amino-terminus followed by several EGF-like repeats and one CUB-domain at the carboxyl terminus. This gene family was termed SCUBE for s ignal-peptide- CUB - E GF-like domain-containing proteins. … * Corresponding authors. Tel.: +49 7071 29 83688; fax: +49 7071 29 5749. Email address: stephan.lindemann{at}med.uni-tuebingen.de meinrad.gawaz{at}med.uni-tuebingen.de
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