Abstract
Aldosterone-binding to plasma proteins was determined in the guinea-pig by equilibrium dialysis, and the metabolic clearance rate (MCR) of aldosterone was calculated from experiments in which the labelled hormone was infused at a constant rate into the circulation during the neonatal period; no specific aldosterone-binding protein was found in the plasma. The hormone was weakly bound to the albumine. The MCR of aldosterone (1/day/100 g body weight) was unchanged from birth to day 8, and its values were similar to those found in adults. Since there was no modification in aldosterone-binding to plasma proteins and no change in the MCR from birth to day 3, the high plasma aldosterone concentrations in the guinea-pig were probably related to intense adrenal activity.
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