Abstract
In this study, 50% ethanol extract prepared from air-dried leaves of nine plants grown wildly in Mongolia were characterized for their inhibitory activity of tyrosinase, -glucosidase, hyaluronidase, lipase, and angiotensin I-converting enzyme (ACE) in order to identify potential new sources for dietary prevention of certain non-communicable diseases and skin health promotion from domestic plant kingdom. The results of this study indicate that out of the selected nine Mongolian plant leaves, V.vitis-idaeae, R.altissimum, and R.acicularis leaves presented strong inhibitory activity of mushroom tyrosinase, R.acicularis and P.anomala leaves exhibited good anti -glucosidase and anti hyaluronidase activity, V.vitis-idaeae leaf showed appreciable inhibition of lipase activity, and P.anomala leaf effectively inhibited ACE. Among them P.anomala and R.acicularis leaves were found to be the most promising natural source with multiple biological properties.
Highlights
IntroductionScientific research into biological activities and phytochemicals of Mongolian plants is rarely carried out
There are approximately 2000 edible and medical plants in Mongolia
L-DOPA (3,4-dihydroxy-L-phenyl-alanine), mushroom tyrosinase (EC 1.4.18.1., activity ∼5771 units/mg of solid), bovine testicular hyaluronidase (EC 3.2.1.35., activity 750-3000 units/mg of solid), compound 48/80, hyaluronic acid sodium salt from rooster comb, intestinal acetone powders from rat were purchased from Sigma-Aldrich
Summary
Scientific research into biological activities and phytochemicals of Mongolian plants is rarely carried out. According to the World Health Organization (WHO), non-communicable diseases such as cardiovascular diseases, diabetes, cancers, and chronic respiratory diseases are currently responsible for almost 70% of deaths globally. According to WHO surveys in Mongolia, cardiovascular diseases (hypertension, stroke and heart attack), cancer, and diabetes make 45% of total morbidity and 63% of mortality, and it was estimated that by 2020 morbidity and mortality could reach 60% and 73% respectively. Cardiovascular diseases have been the leading cause of death among Mongolians, accounting for 42% of female deaths and 35% of male deaths. Cancers are in second place, with 22% of deaths among females and 20% among males. Of all non-communicable diseases, diabetes accounts for 1%, which is 49.9 per 10 000 population. To prevent and control such diseases, reduction of risky behaviors, early detection and developing functional foods with multiple biological properties by using non-traditional food resources are necessary
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