Abstract
Aim of the study was to screen the antimicrobial activity of pyrimidine derivative 3-[2-(1-naphthyl)-2-oxoethyl]-6-bromoquinazoline-4(3H)-oh with laboratory cipher VMA–13–06 in relation to pathogenic and opportunistic flora. Material and methods. Antimicrobial activity of VMA–13–06 was established in vitro against strains of Staphylococcus aureus, Klebsiella pneumonia, Streptococcus pyogenes, Escherichia coli, Acinetobacter baumannii and Citrobacter freundii by the method of serial dilutions, by forming rows with different concentrations of the compound under study. Results. VMA–13–06 was found to exhibit high antibacterial activity against S. aureus, S. pyogenes, E. coli and K. pneumonia at concentrations of 128 and 64 μg/ml comparable to the activity of the comparison drug norfloxacin. At a concentration of 32 μg/ml, the studied derivative is highly active against S. aureus and S. pyogenes and shows average activity against E. coli and K. pneumonia. The compound VMA–13–06 in dilution from 16 to 4 μg/ml is moderately active against the above-mentioned microorganisms. At concentrations from 2 to 0.25 μg/ml, the pyrimidine derivative is inactive against S. aureus, S. pyogenes, E. coli and K. pneumonia, in all dilutions – against C. freundii and A. baumannii. Conclusions. The results of a screening study indicate a pronounced bactericidal effect of VMA–13–06 against S. aureus, S. pyogenes, E. coli и K. pneumonia comparable to the comparison drug norfloxacin.
Highlights
Aim of the study was to screen the antimicrobial activity of pyrimidine derivative 3-[2-(1-naphthyl)-2-oxoethyl]-6-bromoquinazoline-4(3H)-oh with laboratory cipher VMA–13–06
the studied derivative is highly active against S. aureus
ml is moderately active against the above-mentioned microorganisms
Summary
В настоящее время важной проблемой являет- Противомикробная активность пиримидинося разработка современных безопасных и эффек- вого соединения VMA–13–06 устанавливалась в тивных противомикробных средств, что связано с условиях in vitro в отношении штаммов Staphyразвитием антибиотикорезистентности микроор- lococcus aureus, Klebsiella pneumonia, Streptoганизмов, приводящей к появлению устойчивых coccus pyogenes, Escherichia coli, Acinetobacter форм возбудителей инфекционной патологии [1, baumannii и Citrobacter freundii, которые были Tsibizova A.A. et al Screening studies of antimicrobial activity of pyrimidine derivative всех используемых штаммов микроорганизмов. В отношении E. coli и K. pneumonia показывает Вид противомикробного действия производное пиримидина неактивно в отношепроизводного пиримидина устанавливался на нии S. aureus, S. pyogenes, E. coli и K. pneumonia, основании оценки подавления роста микробной во всех разведениях – в отношении С.
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