Abstract
Letters21 April 2009Screening Strategies for HemochromatosisPradyumna D. Phatak, MD, Herbert L. Bonkovsky, MD, and Kris V. Kowdley, MDPradyumna D. Phatak, MDFrom Rochester General Hospital, Rochester, NY 14621; Carolinas HealthCare System, Charlotte, NC 28232; and Virginia Mason Medical Center, Seattle, WA 98101.Search for more papers by this author, Herbert L. Bonkovsky, MDFrom Rochester General Hospital, Rochester, NY 14621; Carolinas HealthCare System, Charlotte, NC 28232; and Virginia Mason Medical Center, Seattle, WA 98101.Search for more papers by this author, and Kris V. Kowdley, MDFrom Rochester General Hospital, Rochester, NY 14621; Carolinas HealthCare System, Charlotte, NC 28232; and Virginia Mason Medical Center, Seattle, WA 98101.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-150-8-200904210-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We appreciate Dr. Thachil's comments regarding the value of serum ferritin measurement as an adjunctive test to serum transferrin–iron saturation in the diagnostic algorithm for hereditary hemochromatosis. We agree that the serum ferritin level is the most useful noninvasive measure of body iron stores in patients with hemochromatosis and can help determine the need for therapeutic intervention. Waalen and colleagues (1) have recommended a ferritin-only screening approach, using a relatively high serum ferritin threshold value of 1000 μg/L (1). Of 59 patients identified in a primary care clinic by using this serum ferritin threshold during a population screening ...
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