Screening outcome in women repeatedly recalled for the same mammographic abnormality before, during and after the transition from screen-film to full-field digital screening mammography.

Abstract

The aim of this study was to retrospectively determine screening outcome in women recalled twice for the same mammographic lesion before, during, and after transition from screen-film (SFM) to full-field digital screening mammography (FFDM). We included women with a repeated recall for the same mammographic abnormality (37 at subsequent SFM-screening, obtained between January 2000-April 2010; respectively 54 and 65 women with a prior SFM-screen or FFDM-screen followed by subsequent FFDM-screening, obtained between May 2009-July 2013). At SFM-screening, repeated recalls for the same lesion comprised 1.2% of recalls (37/3217), including 13 malignancies (positive predictive value (PPV), 35.1%). During the SFM to FFDM transition (SFM-screen followed by FFDM-screen), FFDM recalls comprised more repeated recalls for the same lesion (2.2%, P = 0.002), with a lower PPV (14.8%, P = 0.02). This proportion increased to 2.8% after transition to FFDM (i.e., two successive FFDM-screens), with 16 malignancies (PPV, 24.6%). Invasive cancers at repeated recall were smaller than interval cancers (T1a-c, 79.4 versus 46.8%, P = 0.001), with less lymph node involvement (20.6 versus 46.5%, P = 0.007). More women are repeatedly recalled for the same mammographic abnormality during and after the transition from SFM to FFDM-screening, with comparable cancer risks before and after the transition. These cancers show better prognostic characteristics than interval cancers. • FFDM-screening increases the number of repeated recalls for the same mammographic abnormality. • The PPV of these recalls is comparable before and after transition to FFDM-screening. • Cancers diagnosed after a repeated recall are smaller than interval cancers. • These cancers also show less lymph node involvement than interval cancers.