Abstract
Crude methanol and water extracts of 32 plant species, used for the treatment of infectious diseases in Venda, were screened for in vitro activity against Candida albicans standard strain (ATCC 10231) and five clinical isolates. Water extracts of 16 plant species and methanol extracts of 11 plant species inhibited candidiasis growth. Inhibition at <1 mg/ml, against the C. albicans strains tested, was observed for the methanol extracts of Combretum molle (root), Piper capense (bark), Solanum aculeastrum (fruits), Syzygium cordatum (bark) and Zanthoxylum davyi (bark) as well as the aqueous bark extract of Afzelia quanzensis and root extract of Tabernaemontana elegans. These results implicate that the extracts contain compounds with therapeutic potential against C. albicans.
Highlights
Crude methanol and water extracts of 32 plant species, used for the treatment of infectious diseases in Venda, were screened for in vitro activity against Candida albicans standard strain (ATCC 10231) and five clinical isolates
In this study we screened 32 plant species used as traditional medicine in Venda, in the treatment of infectious diseases, to determine activity against C. albicans standard strain and five recent clinical isolates
Antifungal activity was assessed using the plate-hole diffusion assay of Ieven et al (1979) and the macro-broth tube dilution method defined by the National Committee for Clinical Laboratory Standards (NCCLS, 2002)
Summary
Crude methanol and water extracts of 32 plant species, used for the treatment of infectious diseases in Venda, were screened for in vitro activity against Candida albicans standard strain (ATCC 10231) and five clinical isolates. In this study we screened 32 plant species used as traditional medicine in Venda, in the treatment of infectious diseases, to determine activity against C. albicans standard strain and five recent clinical isolates. The plate-hole diffusion assay served as a screening method to determine whether the plant extracts possessed antifungal activity or not.
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