Abstract
Screening of Tyrosinase Inhibitor, Antioxidant and Cytotoxicity of Dried Sea Cucumber from Tomini Bay, Indonesia
Highlights
Sea cucumber is a group of animals that lives in the sea
This study aimed to investigate the activity of tyrosinase inhibitor, anti
Samples used in this study were dried sea cucumbers that processed by a fisherman in the village
Summary
Sea cucumber is a group of animals that lives in the sea. Sea cucumbers are usually soft-bodied echinoderms, looking like a cucumber, elongated, worm-like organisms, with a leathery skin and gelatinous body.[1]. Objective: The aim of the study was to determine the activity of tyrosinase inhibitors, antioxidants, and cytotoxicity of sea cucumber methanolic extract. Methods: Dried sea cucumber samples were taken from Boalemo waters, Tomini Bay, Indonesia. The DPPH free radical scavenging testing showed that all sea cucumbers had weak antioxidant activity. Cytotoxicity assay revealed that several sea cucumbers had good cytotoxicity against T47D cells, where Holothuria atra and Bohadschia marmorata showed strong cytotoxicities with IC50 values of 23.0 and 28.1 ug/mL, respectively Conclusion: Based on the study, it can be concluded that the dried sea cucumber from the Tomini bay region, Indonesia, has the potential to be developed as a source of tyrosinase inhibitors and cytotoxic agents.
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