Abstract
Objective: The study was designed to determined antidermatophytic activity of Thymus vulgaris essential oil against fungi causing superficial skin infections in human and animal.Methods: Minimum inhibitory concentration (MIC) of essential oil was screened against selected pathogenic fungi namely Trichophyton rubrum (MTCC 296), T. mentagrophytes (MTCC 7687), Microsporum gypseum (MTCC 4524), M. fulvum(MTCC2837), T. soudanense and T. interdigitale through semi solid agar antifungal susceptibility testing method(SAAS). Minimum fungicidal concentration (MFC) was also determined by modified semi solid agar antifungal susceptibility method. T. soudanense and T. interdigitalis were isolated through TO. KA. VA hair bating technique from animal habitats soil of Jaipur district.Results: T. vulgaris essential oil exhibited excellent antideramtophytic activity against all selected dermatophytes. Minimum inhibitory concentration was ranged from 0.020±0.000μl/ml to 0.1±0.033 μl/ml. MFC were found little higher than MIC (0.02±0.000μl/ml to.2±0.000μl/ml). M. gypseum was found to be most susceptible fungus as compared to other test fungi.Conclusion: T. vulgaris was found to be most effective fungicidal agent against human pathogenic fungi. Present findings provide for a rationale basis of a possible utilization of this oil in fields requiring safe and cheap compounds with antiseptic and preservative properties, such as cosmetic, pharmaceutical and food industries.
Highlights
Infection caused by fungi in man and animal are more common in tropical and subtropical countries due to prevailing moisture, over population, poor hygienic living conditions and temperature regimes [1,2,3,4,5]
Data incorporated in table 1 show Minimum inhibitory concentration (MIC) and Minimum fungicidal concentration (MFC) of Thyme essential oil
Data incorporated in present studies revealed strong antidermatophytic activity of T. vulgaris essential oil against all selected filamentous fungi namely T. mentagrophytes, T. rubrum, T. interdigitale, T. soudanense, M. fulvum and M. gypseum
Summary
Infection caused by fungi in man and animal are more common in tropical and subtropical countries due to prevailing moisture, over population, poor hygienic living conditions and temperature regimes [1,2,3,4,5]. Skin infection due to dermatophytes has become a severe health problem affecting children, adolescent and adults They produce keratinase which degrade the keratin and invade the superficial skin tissue, nails and hair. There has been an increase in the incidence of fungal infections in developing countries This may be the result of frequent use of antibiotics, environmental factors, resistant strains and various conditions, like organ transplantation, lymphomas, leukemia and human immunodeficiency virus [7]. Clinical values of these agents have been limited due to having high toxicity and emergence of drug resistance in their antifungal activities [8] These factors emphasize the urgent need for the development of new effective treatment alternatives
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