SCREENING OF STEM BARK EXTRACT OF BAUHINIA VARIEGATA LINN. FOR PHYTOCHEMICAL CONSTITUENTS AND PHARMACOLOGICAL ACTIVITY

Shubham S Gawas Shubham S Gawas,M.h.s Godinho M.H.S Godinho

doi:10.32553/jbpr.v9i3.751

Shubham S Gawas Shubham S Gawas, M.h.s Godinho M.H.S Godinho

Open Access

https://doi.org/10.32553/jbpr.v9i3.751

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Abstract

Bauhinia variegata named orchid tree, belongs to the family leguminosae. The methanolic extract of Bauhinia variegata (MEBV) revealed the presence of carbohydrates, proteins, tannins, steroids, triterpenoids and flavonoids. Various CNS models were used to find out the antianxiety activity of Bauhinia variegata. The study was designed to evaluate the antianxiety activity of stem bark extract of Bauhinia variegata. The effect of dried stem bark of Bauhinia variegata (200 mg/kg and 400 mg/kg) was evaluated using Elevated Plus Maze, Light and Dark Box, Restrained Stress Model and Novelty Suppressed Feeding Test using a wistar albino rats (n=6) and was statistically analyzed using ONE WAY Annova followed by Dunnett’s test. Oral administration of the methanolic extract of Bauhinia variegata (200 mg/kg and 400 mg/kg) showed significant increase in %OAE and %TSOA values for EPM, NEL and TSL values in Light and Dark Box, Restrained Stress Model showed significant increase in %OAE and %TSOA and NEL and TSL values. Novelty suppressed feeding behaivior test showed significantly lower values for latency to feed.From the present study it may be concluded that among both the test groups, MEBV at a dose of 400 mg/kg was found to possess significant anti-anxiety activity. Keywords: EPM- Elevated Plus Maze, NEL- Number of Entries in Light, TSL- Time spent in light.

Highlights

Nature has been source of medicinal agent since time immemorial and man has been dependent on plant products for his needs
It can be said that methanolic extract of B. variegata at a dose of 400 mg/kg possesses highest anti-anxiety activity among the two test groups
Using Restrained Stress model after continuous administration of the extracts, both the doses were subjected to Elevated Plus Maze which demonstrated significant increase in %OAE and %TSOA values for both the doses (200mg/kg and 400mg/kg) of methanolic extract of B. variegata out of which dose of 400 mg/kg of methanolic extract of Bauhinia variegata (MEBV) showed most significant increase

Summary

Introduction

Nature has been source of medicinal agent since time immemorial and man has been dependent on plant products for his needs. The importance of herbs in the cure of human ailment cannot be neglected. Phytomedicines used to cure several diseases are well acknowledged in indigenous traditional system Ayurveda, Unani and Charak Samhita. With growing awareness for the last three decades, it was needed to explore the potential of plant-derived products against several diseases.[1]. Synthetic drugs are known to cause side effects, as a result of which people are more keen on using natural products obtained from plants. Standardization and formulation of the plant product is necessary to describe the isolation, identification and qualification of active ingredients in plant materials. Standardization and formulation of the plant product is necessary to describe the isolation, identification and qualification of active ingredients in plant materials. 2

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