Screening of Phytochemical and Quantitative Lipase Inhibition of Honey and Cinnamon Paste: A Synergistic Effect

Abstract

Objective: Obesity is one among the metabolic syndromes caused due to the disproportion in intake and disbursement of energy, it takes the reasons for many non-communicable diseases or chronic disorders like diabetics, heart diseases etc. An imbalanced diet with a composition of high fat foods are the common causative agents for obesity. There are many synthetic therapeutic methods to prevent and reduce obesity which always ends with side effects. The study involves in estimating the anti-obesity properties of honey and cinnamon individually and also their synergistic effect in inhibiting the pancreatic lipase. Methods: Ethanol extract was prepared for honey, cinnamon and their combinations, the qualitative phytochemical screening were done with their standard procedures. Porcine Pancreatic lipase activity was done for the samples at different concentrations from 10 to 60µg/ml. Results: The present study reveals the presence of all tested phytochemicals in the honey-cinnamon paste. With the increase in the concentration of extracts the higher inhibition of the lipase enzyme was observed. Percentage of inhibition ranged from honey 8.48±.041 to 41.49±0.14%, cinnamon 14.48±0.45 to 60.74±0.19% and honey-cinnamon pastes 23.48±0.20 to 87.37±0.20% respectively. Conclusion: The lipase inhibition effect reveals that the honey-cinnamon paste has a synergistic effect against lipase which could positively inhibits and reverts obesity which in turn eventually protects from obesity related non-contagious diseases.