Abstract
A library of 600 taxonomically diverse Panamanian plant extracts was screened for DPPH scavenging and UV-B protective activities, and the methanolic extracts of Mosquitoxylum jamaicense, Combretum cacoucia, and Casearia commersionia were submitted to HPLC-based activity profiling. The compounds located in the active time windows were isolated and identified as gallic acid derivatives and flavonoids. Gallic acid methyl ester (3) and digallic acid derivatives (2, 6) showed the highest DPPH scavenging activity (<10 μg/mL), while protocatechuic acid (7) and isoquercitrin (10) exhibited the highest UV-B protective properties.
Highlights
The skin is the largest organ of the human body, functioning as an effective barrier against the harmful effects of the environment [1]
Natural products play a major role as active ingredients given that they are considered by many as safer alternatives to synthetic products and, possess higher consumer acceptance
A library of 600 extracts prepared from Panamanian plants was screened for antioxidant capacity and the ability to protect human skin fibroblasts against UV-B-induced cell death
Summary
The skin is the largest organ of the human body, functioning as an effective barrier against the harmful effects of the environment [1]. A library of 600 extracts prepared from Panamanian plants was screened for antioxidant capacity and the ability to protect human skin fibroblasts against UV-B-induced cell death. The MeOH leaf extract of Mosquitoxylum jamaicense showed activity in time windows corresponding to UV-absorbing peaks in the HPLC chromatogram (Fig. 2B).
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