Screening of Natural Antioxidants from Traditional Chinese Medicinal Plants Associated with Treatment of Rheumatic Disease

Feng-Lin Song,Ren-You Gan,Yuan Zhang,Lei Kuang,Hua-Bin Li,Xiang-Rong Xu,En-Qin Xia

doi:10.3390/molecules15095988

Abstract

In order to find new sources of natural antioxidants, the antioxidant capacities of 50 medicinal plants associated with treatment of rheumatic diseases were systemically evaluated using the ferric-reducing antioxidant power (FRAP) and Trolox equivalent antioxidant capacity (TEAC) assays, and their total phenolic contents were measured by the Folin–Ciocalteu method. Their antioxidant activities of some of these plants were analyzed for the first time. The FRAP and TEAC assay results suggested that the antioxidant compounds in these plants possessed free radicals scavenging activity and oxidant reducing power. A positive linear correlation between antioxidant capacities and total phenolic contents implied that phenolic compounds in these plants could be the main components contributing to the observed activities. The results showed that Geranium wilfordii, Loranthus parasiticus, Polygonum aviculare, Pyrrosia sheaeri, Sinomenium acutum and Tripterygium wilfordii possessed the highest antioxidant capacities and total phenolic content among 50 plants tested, and could be rich potential sources of natural antioxidants.

Highlights

Free radical-induced oxidative damage is involved in the pathogenesis of many chronic and degenerative diseases, such as cardiovascular disease, cancer, diabetes, neurodegenerative disease and ageing [1,2,3,4,5]
There has been an increasing interest in natural antioxidants in Chinese medicinal plants (CMPs), and the health benefits of CMPs are thought to arise partly from the potential effects of their antioxidants on the reactive oxygen species produced in the human body
The antioxidant capacities of 50 medicinal plants associated with the treatment of rheumatic diseases were evaluated using the ferric-reducing antioxidant power (FRAP) and Trolox equivalent antioxidant capacity (TEAC) assays, respectively

Summary

Introduction

Free radical-induced oxidative damage is involved in the pathogenesis of many chronic and degenerative diseases, such as cardiovascular disease, cancer, diabetes, neurodegenerative disease and ageing [1,2,3,4,5]. Antioxidants are substances capable of scavenging ROS and protecting from oxidative damage. Natural antioxidants, such as vitamins and polyphenols, have high antioxidant capacities and are abundant in many fruits and vegetables, whose consumption has been demonstrated to be inversely associated with the cardiovascular disease and some cancers [8]. Evaluation of antioxidant activity of CMPs is very important because some plants possessing high antioxidant capacities, which are potentially valuable sources of natural antioxidants, could be screened out. Several studies indicated that some CMPs possessed more potent antioxidant activities than common fruits and vegetables [12,17]

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