Abstract
Background: Parkinson's disease (PD) is a neurodegenerative disorder accompanied by depletion of dopamine and loss of dopaminergic neurons (DA) in the brain that is believed to be responsible for the motor and non-motor symptoms of PD. Parkin belongs to the RBR family of E3 ubiquitin ligase, which is involved in varied cytosolic and mitochondrial functions. Parkin mutations lead to early synaptic damage and appear as a crucial gene having a vast functioning area in PD.
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