Abstract
Objective: Screening of industrial important bioactive metabolites of Antibiotics, hydrolytic enzymes producing microorganism from garden soil of Dr. M. G. R Educational and Research Institute, Chennai.
 Methods: Desired ten soil samples taken and were serially diluted. Crowded plate method used for antibiotic-producing microorganism and Starch agar medium and gelatin medium tests were performed for hydrolytic enzymes (Amylase and Gelatinase).
 Results: Among the tested soil samples, antibiotic producing microorganisms were not found, but has hydrolytic enzymes amylase and gelatinase. Thus screened soil samples biochemically identified as Bacillus species.
 Conclusion: This study concludes that, the collected sample, produced Antibiotic negative result and it’s possess other industrial important hydrolytic enzymes. Thus Screening of more bioactive metabolites producing ability from a single isolate, will be more useful for effective screening.
Highlights
Plants, animals and marine sources are used for the discovery of new drugs
We aimed for screening of industrial important bioactive metabolites antibiotics producing microorganism along with their isolates possesses any industrial important hydrolytic enzymes (Amylase and Gelatinase) producing ability
All the 10-5 serially diluted ten samples, after 72 h incubation at 37 °C not produced any clear zone around the developed colonies, the growth was found as shown in the fig no: 1. Further to observe the effect of time duration extension, on secondary metabolites antibiotics, producing ability of microorganism were monitored [11, 19, 20] in all the plates which were incubated up to 5 d at 37 °C
Summary
Animals and marine sources are used for the discovery of new drugs. To fulfill the demands, overcoming snags, challenges and safer economics, microorganisms are widely used as source for new drugs. An enormous variety of bioactive metabolites with different therapeutic properties have been isolated from several microbial species due to their rapid growth, constant and eternal source [2,3,4,5]. Screening of antibiotic from soil would be normally practical [7,8,9] as well as single sample isolates may not possess a positive activity and microbial origin, meet industrial demand [10]. We aimed for screening of industrial important bioactive metabolites antibiotics producing microorganism along with their isolates possesses any industrial important hydrolytic enzymes (Amylase and Gelatinase) producing ability
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