SCREENING OF MICRO- AND MACROVASCULAR COMPLICATIONS IN NEWLY DIAGNOSED DIABETES MELLITUS PATIENTS WITH MYCOBACTERIUM TUBERCULOSIS INFECTION, AT TERTIARY CARE CENTER IN NORTHERN INDIA

Abstract

To screen for micro- and macrovascular complications in patients with newly diagnosed diabetes mellitus and mycobacterium tuberculosis infection. Total 182 patients infected with TB were enrolled in the study. Patients of TB were selected from Medicine and Pulmonary Medicine departments in MLN Medical College Prayagraj. They were evaluated for glucose intolerance at the time of enrollment. Patients who did not have previous diagnosis of diabetes had samples drawn for A1C and on a subsequent day have an OGTT on a fasting state. In all patients diagnosed with glucose intolerance and tuberculosis infection, ECG, 2 D Echo, CIMT (carotid intima media thickness), fundus examination was done and ABPI (ankle brachial pressure index) was calculated. 18 patients who had known history diabetes and were on diabetic medications were excluded. Out of 164, total 88 (53.66%) patients had normal glucose tolerance (NGT) and 76 (46.34%) had abnormal glucose tolerance (AGT). AGT group included patients with impaired glucose tolerance (IGT) and newly diagnosed diabetes mellitus. In the AGT group 50 (30.49%) patients were diagnosed as prediabetes and 26 (15.85%) were as newly diagnosed diabetes mellitus. Seven (9.21%) newly diagnosed diabetic patients had ABPI below 0.89 and fundus abnormalities (9.21%, p=0.012). Urine microalbuminuria >300md/dl was present in seven patients (9.21%, p<0.001), ECG abnormalities with ST-T changes and 2D-Echo ndings of diastolic dysfunction were found in 4 (5.26%, p=0.095), and 5 (6.58% p=0.047) in newly diagnosed DM patients. Newly diagnosed diabetic patients had micro- and macrovascular complications associated with them at time of their diagnosis