Abstract
Topicality. Diabetes mellitus is an important social and medical problem, as it causes the development of dangerous complications that lead to disability and mortality. This disease is characterized by a multi-vector pathogenesis that requires a comprehensive approach to treatment. Due to the use of mixtures of medicinal plants in the treatment of diabetes, it is possible to cover all aspects of the development of this disease and its complications. In addition, the niche of the pharmaceutical market of Ukraine with phytomixtures is almost empty.Aim. To study the hypoglycemic activity of the herbal mixtures, which are used in folk medicine for diabetes mellitus type 2 prevention and treatment, but do not have a scientific basis and to establish their conditional therapeutic dose.Materials and methods. The study has been performed in male albino rats weighing 180-200 g, during 20 days they have been receiving orally for preventive treatment aqueous extracts (1:10) of the studied herbal mixtures at a dose 6 mL/kg/day, 9 mL/kg/day and 12 mL/kg/day and comparison drugs – the official herbal mixtures “Arfazetin” at a dose 9 mL/kg/day and tablets metformin at a dose 60 mg/kg/day. The study of hypoglycemic properties and the establishment of a conditional therapeutic dose of the studied mixtures was carried out using glucose loading tests. All experiments have been performed in accordance with general ethical principles with the recommendations of the EEC Council directive 2010/63/EU about the protection of animals used for scientific experiment.Results and discussion. The results of the study showed the 20-day preventive treatment by the herbal mixtures reduced alimentary hyperglycemia at the 30th minutes of OGTT and helped regulate carbohydrate tolerance disorders by reducing hyperglycemia at the 15th minutes of IPGTT. The highest hypoglycemic activity showed the herbal mixture No. 7 in a dose 12 mL/kg/day, which was almost on a par with the comparison drug – tablets metformin, but exceeded the official herbal mixture “Arfazetin”. In addition, the dose-dependence of the effectiveness of all five studied herbal mixtures was established.Conclusions. For the first time, it was conducted the screening study of hypoglycemic activity of the herbal mixtures, which are used in folk medicine for the prevention and treatment of diabetes mellitus type 2. It was determined that the greatest effectiveness in terms of the ability to reduce alimentary hyperglycemia during OGTT and reduce impaired carbohydrate tolerance during IPGTT show the herbal mixture No. 7, which includes Inulae rhizomata et radices, Helichrysi arenarii flores, Maydis style cum sigmatis, Origani herba, Rosae fructus, Taraxaci radices. It was established its conditional therapeutic dose 12 mL/kg/day.
Highlights
Diabetes mellitus is a global social problem in the field of health care, due to rapid spread of this disease and the development of serious complications such as microand macroangiopathies, which significantly reduce the quality and life expectancy of patients [1]
It was conducted the screening study of hypoglycemic activity of the herbal mixtures, which are used in folk medicine for the prevention and treatment of diabetes mellitus type 2
It was determined that the greatest effectiveness in terms of the ability to reduce alimentary hyperglycemia during Oral Glucose Tolerance Test (OGTT) and reduce impaired carbohydrate tolerance during intraperitoneal glucose tolerance test (IPGTT) show the herbal mixture No 7, which includes Inulae rhizomata et radices, Helichrysi arenarii flores, Maydis style cum sigmatis, Origani herba, Rosae fructus, Taraxaci radices
Summary
Diabetes mellitus is a global social problem in the field of health care, due to rapid spread of this disease and the development of serious complications such as microand macroangiopathies, which significantly reduce the quality and life expectancy of patients [1]. An important problem of pharmacovigilance is that existing pharmacotherapy can effectively reduce hyperglycemia, but it is not always able to stabilize fluctuations zn glycemic values during the day and maintain it at an optimal level. This leads to the formation of a cascade of pathological processes – excessive glycation and inactivation of the body’s antioxidant defense system, triggering the processes of free radical oxidation of lipids and, as a the development of oxidative stress, which leads to the development and progression of diabetic angiopathies [1, 3, 4]. The combination of different medicinal plants is worth a particular attention, because such herbal mixtures will have more biologically active substances and will influence on the all links of the pathogenetic mechanism of development of [23]
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