Abstract
Alpha glucosidase inhibitor is one of therapeutic approaches for diabetes mellitus which is known for its safety compare to other oral anti diabetic drugs. Therefore searching of α - glucosidase inhibitor from natural compounds was recently done by many researchers to find the new active compounds. Endophyt ic fungi have great potential as a source of α - glucosidase inhibitory compounds. This research aims to isolate the endophytic fungi from Cassia siamea Lamk. leaves and then to evaluate their α - glucosidase inhibitory activity. We successfully isolated five endophytic fungi colonies, and then each isolat e was fermented and extracted with ethyl acetate and methanol. Each extract was assayed for its α - glucosidase inhibitory activity using spectrophotometry method. Nine extracts showed better α - glucosidase inhibitory than acarbose with the smallest IC 50 valu e was 28.40 ppm.
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