Abstract

Corona Virus Disease 2019 (COVID-19) is an emerging disease announced by World Health Organization (WHO) as a pandemic disease since March 2020. Several international guidelines suggested use of reverse transcriptase polymerase chain reaction (RT-PCR) test as screening tool before starting gastrointestinal (GI) procedures. Although RT-PCR is a gold standard, it has limitation as it is expensive and requires special expertise therefore difficult to implement in limited resource hospitals. Due to lack of RT-PCR tests available and in accordance with Indonesian government regulation, thirty patients in a tertiary referred hospital in Banda Aceh were screened with rapid test antigen and antibody for COVID-19 before underwent emergency and urgency GI procedures such as endoscopy, colonoscopy and abdominal ultrasonography. Several laboratory parameters and chest X-ray in all patients were assessed. All health care workers in procedure room were also tested with rapid antigen 1 week after the procedures. The study showed that laboratory parameters and chest X-ray were relatively normal for all patients. All procedures were conducted safely and leave no new COVID-19 case amongst health care workers. In conclusion, rapid test can be used in hospitals with limited resources, although RT-PCR test is still needed to confirm COVID-19 cases. Safe GI procedures can still be performed in limited resource hospital, although the possibility for disease transmission is still high. A modified guideline is needed in these hospitals in order to conduct safe GI procedures.

Highlights

  • The world and medical community have experienced a huge viral pandemic since months ago named Corona Virus Disease 2019 (COVID-19)

  • International gastroenterology and gastrointestinal endoscopy societies have published guidelines and position statements focusing on endoscopy in the era of COVID-19 [1]

  • All guidelines and recommendations suggest COVID-19 nucleic acid reverse transcriptase polymerase chain reaction (RT-PCR) testing must be done before gastrointestinal procedures within 3 days before endoscopy, combination of Immunoglobulin (Ig) M and G antibodies against SARS-CoV-2 demonstrated 84.5% sensitivity and 91.6% specificity

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Summary

INTRODUCTION

The world and medical community have experienced a huge viral pandemic since months ago named Corona Virus Disease 2019 All guidelines and recommendations suggest COVID-19 nucleic acid reverse transcriptase polymerase chain reaction (RT-PCR) testing must be done before gastrointestinal procedures within 3 days before endoscopy, combination of Immunoglobulin (Ig) M and G antibodies against SARS-CoV-2 demonstrated 84.5% sensitivity and 91.6% specificity. Some guidelines suggest patients undergo 3-hour rapid testing on the day of gastrointestinal procedures [8], [9]. If no COVID-19 RT-PCR examination is available, all symptomatic/contact history patients are considered high risk patients for undergoing GI procedures [8]. A single RT-PCR test kit may cost over 100 USD, while setting up a diagnostic/processing lab requires more than 15,000 USD. The study aimed to analyze the use of antibody and antigen-based rapid tests to select patients for GI procedures and its impact on transmission of COVID-19 to the health care workers

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