Abstract
To screen and identify the antimicrobial ingredients of Forsythia suspensa leaves (FL). A screening method based on a constituent knock-out/knock-in strategy was conducted. The antimicrobial activities of FL components against seven commonly infective strains were determined using the Oxford cup method. Their antimicrobial effects when used in combination with common antibiotics were investigated by a checkerboard titration method. Two of the seven strains, Staphylococcus aureus and methicillin-resistant S. aureus (MRSA), were considered to be the most sensitive to the inhibitory effect of FL. The main antimicrobial components in FL were forsythoside I and forsythoside A. The co-administration of vancomycin with forsythoside A was found to have a significant synergistic inhibiting effect on MRSA. Some phenylethanol glycoside components play a major contribution to the antimicrobial effect of FL. This provides a reference for the research and development of FL for both medicinal and food purposes.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
