Abstract
Purpose: Synthetic chemistry is an important route to develop new therapeutics for every disease. The presented research is focusing on the design, synthesis, evaluation, and Lipinski’s rule approach for a new biologically active benzimidazole derivative.
 Methods: The synthesis comprises the reaction between lactic acid and o-phenylenediamine (OPD) to produce a corresponding product followed by self-condensation for obtaining a complex multiple.
 Results: The newly produced composite was found to hold weighty anthelmintic property when we compared the same with Albendazole(Standard drug). When the concentration of the desired compound increases paralysis as well as death time found to decreases respectively. 50µg/ml of the synthesized drug gave a time for paralysis is 30.43 ± 5.33 min & time for death is 0.56 ± 5.32 min.
 Conclusion: The synthesized final compound showed to have anthelmintic activity and its orally active property was also predicted from the Molinspiration software using physicochemical (RO5) as well as bioactive limits. It can be used for anthelmintic drugs as an oral formulation.
Highlights
The structural variation of benzimidazole derivatives is so convenient for the expansion of molecules of therapeutic or biological interest
Heterocyclic compound, derivatives of benzimidazole have a vital place in the arena of synthetic medicinal chemistry
The attachment of a benzimidazole nucleus in the desired moiety have a significant role for beneficial pharmacologic activity
Summary
The structural variation of benzimidazole derivatives is so convenient for the expansion of molecules of therapeutic or biological interest. Benzimidazole derivatives with different substitutions on different positions have found to be sources of much pharmacological utility. They are used in the treatment of ulcer, hypertension, viral & fungal infection, cancer, and antihistaminics, etc [1]. Various new scheme for the preparation of benzimidazole derivatives have been reported and synthesized with an intention of searching for its enhanced therapeutic values. Anthelmintics are the drugs that kill or removed out parasitic worm from the living body. They are sometimes called vermicides or vermifuges
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