Abstract

Introduction: Cancer is considered as the prime lethal disease that affects different organs of the body. Even with the rapid developments in the medical sciences, there are no proper medicines to cure specific kind of cancer without side effects. The inhibition of tumour cell growth without side effects either by the use herbal or synthetic drugs is considered as an important target in cancer therapy. In traditional medicinal system A. semecarpifolia stem bark is the prime source of herbal drug to treat lymphatic and skin cancers. Objective: The purpose of this study is to evaluate the anticancer potential of A. semecarpifolia stem bark extracts against some cancer cell lines. Methods: The in vitro anticancer activity was evaluated against DLA, EAC, HeLa, HepG2 and L929 cell lines by trypan blue dye exclusion assay and SRB assay. Results: The results of the anticancer activity revealed that, when compared to standard drug Cyclophosphamide, SBPEE and SBCE of A. semecarpifolia showed significant anticancer activity against DLA and EAC cell lines, without causing any toxicity to the normal mouse fibroblast cells L929. Whereas, none of the three extracts showed cytotoxicity against HeLa, HepG2 and L929 cell lines. Conclusion: The present study suggested that, SBPEE and SBCE possesses significant cytotoxic activity against DLA and EAC cell lines, which confirms the traditional medicinal claim of A. semecarpifolia as a potent anticancer plant against lymphatic and skin cancer.

Highlights

  • Cancer is considered as the prime lethal disease that affects different organs of the body

  • The in vitro anticancer activity was evaluated against Dalton’s Lymphoma Ascites (DLA), Ehrlich Ascites Carcinoma (EAC), HeLa, HepG2 and L929 cell lines by trypan blue dye exclusion assay and Sulforhodamine B (SRB) assay

  • The present study suggested that, Stem Bark Petroleum Ether Extract (SBPEE) and Stem Bark Chloroform Extract (SBCE) possesses significant cytotoxic activity against DLA and EAC cell lines, which confirms the traditional medicinal claim of A. semecarpifolia as a potent anticancer plant against lymphatic and skin cancer

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Summary

Introduction

Cancer is considered as the prime lethal disease that affects different organs of the body. In traditional medicinal system A. semecarpifolia stem bark is the prime source of herbal drug to treat lymphatic and skin cancers. Conclusion: The present study suggested that, SBPEE and SBCE possesses significant cytotoxic activity against DLA and EAC cell lines, which confirms the traditional medicinal claim of A. semecarpifolia as a potent anticancer plant against lymphatic and skin cancer. Cancer is a disease caused by loss of cell cycle control, in which there is an uncontrolled multiplication of the cells.[1] It is associated with abnormal and uncontrolled cell growth. It is a significant health problem worldwide, generally due to the lack of early detection methods. Controlling the rapid multiplication of the cancer cells without affecting the normal cells is a challenging task in the discovery of anticancer compounds

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