Abstract
The Supersome assay has long been used for industrial purposes to identify possible in vitro drug-drug interactions. Many of these interactions occur via induction or inhibition of the cytochrome P450 (CYP P450) enzyme system. The CYP P450 are a superfamily of membrane-bound, haeme-thiolate proteins, which are principally responsible for phase 1 oxidative metabolism and detoxification of xenobiotics and endobiotics (e.g. steroids, fatty acids, retinoids, eicosanoids, vitamins, cholesterol and prostaglandins).
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