Abstract
The German Chemicals Act (Chemikaliengesetz) requires that new chemicals be tested for toxicity according to a stepwise procedure based on production quantities. If the expected total annual production exceeds 1,000 tons, screening for “behavior-disrupting properties” is required as part of chronic toxicity testing. A test guideline based on cageside observations was published in 1985. The protocol covers outer appearance as well as motor, sensory, and autonomic functions and signs indicative of central nervous system (CNS) functions. So far, no chemical has been screened for behavioral toxicity according to this guideline because the expected production quantities never exceeded the threshold required for chronic toxicity testing.
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