Screening for late effects after childhood cancer in adults

Abstract

In recent decades, long-term survival after childhood/adolescent cancer has steadily improved and 5-year survival rate is over 80% for most entities. Studies have shown that more than two thirds of these long-term survivors develop new diseases associated with the treatment, so-called late effects, that occur years to decades after the end of cancer therapy. Risk-adapted screening examinations are recommended to ensure early diagnosis and treatment of late effects. These examinations are offered by interdisciplinary long-term follow up (LTFU) teams.In order to facilitate standardized LTFU worldwide, the International Guideline Harmonization Group (IGHG) was founded from representatives of various disciplines involved in LTFU. The evidence-based follow-up guidelines created by this group replace national recommendations.Numerous new IGHG guidelines have been published in recent years. The following topics are presents as examples:Breast Cancer Screening: Due to an increased risk of breast cancer, female patients should be included in intensified screening programs after thoracic radiotherapy. This now includes patients exposed to a radiation dose of 10 Gray and more.Bone density: Various cancer treatments elevate the risk for low bone density. Therefore, these patients should receive early bone density measurement.Mental health and fatigue: Mental illness and Fatigue can occur years to decades after cancer and should be regularly addressed during follow-up.