Abstract
Aim: To screen hepatitis B and C in occupational setting. Methods: Cross-sectional study multicenter in 16 enterprises (one occupational exposure; 5602 agents). Screening was preceded by information, sensibilisation and informed consenting physician labor, labor union and agents. Hepatitis B surface antigen (HBsAg) and antibodies anti-hepatitis C (Elisa, third generation) were tested in all. For those with HBsAg positive, this test was completed by IgM and IgG, anti HBc, HBeAg, antibodies anti HBe, transaminases and HBB DNA; for those with positive anti-VHC antibodies, test was completed by transaminases and VHC’s RNA. Results: Rate of participation was 76.2% (4268/5602 labors). HBsAg or hepatitis C antibodies were positives in 425 (9.9%) of cases (HBsAg positive: 8.48%; Hepatitis C Antibodies positives: 1.50%; both: 0.05%). In HBsAg positive, viral replication and cytolysis were seen respectively in 2.5 % and 18.2%. According with transaminases, serologic markers and viral load, immunotolerance, inactive and immuno active phase were suspected in 0.56%, 80.9% and 1.6% of cases. In hepatitis C antibodies positives persons, any had viral replication but cytolysis was observed in 33.3% (n = 21). HBsAg was significantively (p < 0.00001) higher in exposed occupational enterprise versus non-occupational setting (14.4% vs 7.8%). They were no differences (p = 0.71) about hepatitis C antibodies in the two setting (1.8% vs 1.7%). Conclusion: Prevalence of HBsAg and hepatitis C antibodies was high in occupational setting in hepatitis endemic country. It’s important to screen all of person in these setting with no consideration with blood exposed or not exposed enterprise.
Highlights
In Ivory Coast, hepatitis B (HVB) and C (HVC) are endemic with 13% and 3% of prevalence [1] [2] [3] [4], they do not, because of their lack of knowledge, screen systematically [5]
Hepatitis B surface antigen (HBsAg) and anti-hepatitis C virus (HCV) antibodies were sought in all. For those with HBsAg positive, this test was completed by IgM and IgG, anti HBc, HBeAg, antibodies anti HBe, transaminases and HBB DNA; for those with positive anti-VHC antibodies, test was completed by transaminases and HCV’s RNA
This study is the only one of sub-Saharan countries in professions with not a risk to exposure to viral hepatitis B and C. These results suggest that on the one hand screening for viral hepatitis B and c should be systematic in firms
Summary
In Ivory Coast, hepatitis B (HVB) and C (HVC) are endemic with 13% and 3% of prevalence [1] [2] [3] [4], they do not, because of their lack of knowledge, screen systematically [5] This disease generates a high cost for its management [6]. As with the fight against HIV, these companies could be an important lever to fight this disease by offering screening, vaccination and access to treatment to its employees [6]. The goal of our work was to evaluate by screening testing the prevalence of hepatitis B and C viruses among workplace where employees are exposed or not to the professional contamination by these viruses
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