Abstract
An increased risk of fetal Down's syndrome (trisomy 21) is the most common reason for offering prenatal genetic diagnosis. The chance of giving birth to a child with Down's syndrome increases throughout a woman's reproductive years. Since the 1970s, an age of 35 years at delivery has been used as the cutoff for offering amniocentesis for this indication in the United States. After this age, the risk of Down's syndrome rises rapidly and is thought to balance the risks of amniocentesis. Nondirective counseling enables couples to compare the risk and burden of Down's syndrome with the risks, accuracy, and limitations . . .
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