Abstract
1. Down's Syndrome (DS) epidemiology and biochemical screening 2. Perception of risk 3. Risk estimation in DS screening policy and practice 4. Screening test combination: a statistical overview 5. Measurement of human chorionic gonadotrophin (hCG) as a screening test for DS 6. The measurement of hCG subunits in screening for DS 7. The measurement of free beta hCG in screening for DS 8. Multiple hCG-related molecules 9. Is the measurement of unconjugated oestriol of value in screening for DS? 10. Inhibin and CA125 in DS screening 11. SPI in DS screening 12. Ultrasound and DS 13. Prenatal diagnosis using fetal cells isolated from maternal blood 14. Rapid detection of chromosome aneuploidies in uncultured fetal cells using fluorescence in situ hybridization 15. Organisation of screening programmes - a British experience 16. The California experience 17. The Dutch experience 18. French experience 19. The United Kingdom national external quality assessment scheme for screening for DS 20. Training obstetricians and midwives to offer serum screening for DS 21. Biochemical screening for DS in the first trimester 22. Screening for DS 23. Mid-trimester biochemistry in prediction of 3rd trimester complications.
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