Abstract
In the presence of NADPH, dihydropryimidine dehydrogenase (DPD) catalyzes the rate-limiting step in the catabolism of pyrimidine bases, including uracil, thymine, and the anticancer agent 5-fluorouracil (5-FU; [Fig. 1][1]). Following bolus and continuous infusion administration of 5-FU, about 90%
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