Abstract
Background Chlamydia trachomatis infection is one of the most prevalent sexually transmitted diseases in the world, which may lead to reproductive tract pathology and adverse pregnancy outcomes. Objective The aim of this study was to evaluate the prevalence of C. trachomatis infection in women with unexplained recurrent miscarriage. Patients and methods A total of 60 women with two or more consecutive spontaneous pregnancy losses with no apparent cause were enrolled in this prospective cohort pilot study, according to the RCOG recurrent miscarriage management guidelines. All participants were screened for chlamydial infection by enzyme-linked immunosorbent assay (ELISA) for detection of serum-specific antibodies and by real-time, fully automated PCR (Real-TM PCR) assessment of endocervical specimens. Results The overall prevalence of chlamydial infection as detected by both ELISA and Real-TM PCR was 6.6% (4/60). The prevalence of current chlamydial genital infection as detected by real-time PCR and anti-chlamydial IgM antibody was only 1.6% (1/60). Conclusion Frequency of chlamydial infection in Egyptian women with unexplained recurrent miscarriage is relatively low. In the setting of recurrent miscarriage investigations, screening for C. trachomatis among Egyptian women is not justified. ELISA offers a simple and cheap screening test as an alternative to the PCR method.
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