Abstract
ObjectiveIn this study, we aimed to screen for Rho GTPase-activating protein 29 gene (ARHGAP29) variants in Turkish paediatric patients with non-syndromic cleft lip with or without cleft palate (nsCL/P). MethodsOur study comprised 80 nsCL/P patients and 125 unrelated Turkish individuals. Molecular analysis of the ARHGAP29 variants was carried out using polymerase chain reaction amplification and direct sequencing. ResultsIn this study, rs141866812, rs143877998, rs147752270, rs141653334, rs149136237, rs374087471, rs144585524 and rs201618253 single nucleotide polymorphisms in exons 2, 21 and 23 of ARHGAP29 were screened in patients with nsCL/P and in the control group. Mutations in the ARHGAP29 gene, which were previously identified in patients with nsCL/P of different ethnicities, were not observed in the Turkish patients. ConclusionThis is the first report investigating ARHGAP29 variants in Turkish patients with nsCL/P.
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