Abstract
Colorectal cancer and diabetes mellitus represent a major public health issue, fi rst, by the number of new cases which are at an alarming rate. Secondly, by the negative effect over the quality of life, socio-economic status and lifespan, representing high morbidity and mortality causes. Diabetes Mellitus is the disease of the century with a global prevalence (standardised-age) which doubled since 1980, rising from 4.7% to 8.5% in adult population. In 2012, the estimated number of fatalities caused by diabetes mellitus and other related complications were at 3.7 million, out of which 43% were patients under the age of 70. Neoplasia represents the second cause of death, after cardiovascular disease. Colorectal cancer (CRC) ranks the 3rd regarding the global neoplasia incidence (10.2%) and the second regarding the mortality (9.5% of all cancer deaths). Colorectal cancer screening refers to the periodic evaluation of asymptomatic patients at risk of developing this neoplasia. Colorectal cancer has a number of peculiarities that make it ideal for screening. Since the end of the 19th century, the suspicion has been raised that diabetes mellitus has been involved, through directly etiological mechanisms, in carcinogenesis (breast, endometrium, colorectal, pancreas, liver, non-Hodgkin lymphoma). At the moment, there is already a consensus in the literature on the role of diabetes as an independent risk factor for colorectal cancer. However, despite the existence of numerous experimental evidence, epidemiological studies and meta-analyses, there is currently no adaptation of colorectal cancer screening for these patients. Material and method: Prospective case-control study conducted over a 2-year period including a number of 442 patients presented at „Dr. I Cantacuzino” Clinical Hospital, asymptomatic, who underwent lower digestive endoscopies in order to assess and defi ne using anamnestic, clinical and paraclinical criteria, the profi le of the patient with type II diabetes mellitus that should be given an endoscopic examination because diagnosing precursor lesions or even CRC is likely probable. Results: In the analyzed group, statistically signifi cant correlations (p<0.05) were recorded between positive colonoscopy results (defi ned as precursor lesions – polyps- or tumors) and certain clinical characteristics (age, sex, BMI, duration of diabetes, type of antidiabetic treatment) and also paraclinical (reactive C protein and glycated hemoglobin). Conclusions: Criteria of patients with type II diabetes who have the maximum probability of developing colorectal cancer have been outlined. Thus this patient is more likely male, with a BMI > 25, aged over 60 years, with an unbalanced diabetes mellitus counted by HbA1c > 7 mg/dL, with over 5 years of diabetes evolution, in treatment with insulin most likely or combined insulin with oral antidiabetics and with an inflammatory biological profi le expressed by PCR> 2 mg/dL threshold values.
Highlights
Colorectal cancer and diabetes mellitus represent a major public health issue, first, by the number of new cases which are at an alarming rate
Analyzing the 2 groups, we found that in terms of body mass index (BMI), the distribution of patients with positive colonoscopy results was similar, with a maximum in the 25-29.99 group
Analyzing the duration of the evolution of diabetes from the time of diagnosis to colonoscopy, we found that most results were in the 5-9.9 year category
Summary
Colorectal cancer and diabetes mellitus represent a major public health issue, first, by the number of new cases which are at an alarming rate. Diabetes Mellitus is the disease of the century with a global prevalence (standardised-age) which doubled since 1980, rising from 4.7% to 8.5% in adult population. Conclusions: Criteria of patients with type II diabetes who have the maximum probability of developing colorectal cancer have been outlined This patient is more likely male, with a BMI > 25, aged over 60 years, with an unbalanced diabetes mellitus counted by HbA1c > 7 mg/dL, with over 5 years of diabetes evolution, in treatment with insulin most likely or combined insulin with oral antidiabetics and with an inflammatory biological profile expressed by PCR> 2 mg/dL threshold values. According to data published by the Ministry of Health (National Study on the Prevalence of Diabetes), in 2017 there were 1 785 300 cases of diabetes in adults aged 20 to 79 years in Romania. In the global hierarchy of cancers, in terms of incidence, colorectal cancer occupies the 3rd place in men (1.026.215 cases, 10.9% of the total), after lung and prostate cancer and 2nd in women (82.303 cases, 9.5% of the total) after breast cancer (Figure 1)[4]
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