Abstract
An target molecule affinity-LC-ESI-MSnmethod was established to rapid screening α-glucosidase inhibitors from total saponins of ginseng stems and leaves. As a result,the inhibitory effects from twelve compounds including ginsenoside Rb3 presented α-glucosidase were observed and identified,meanwhile,five of them including ginsenoside F2,Rf,Rg3,Rd and Rb3 were done for activity validation. Rb3 showed the strongest activity for α-glucosidase,inhibition rate is 43. 16%,close to total saponins. The method is simple,rapid,accurate and suitable for directly screened active ingredients which can inhibit α-glycosidase from complex extract of traditional Chinese medicines.
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