Abstract
PurposeThis research aimed at ascertaining the effects of prebiotic exopolysaccharide on inflammatory bowel disease (IBD). MethodsWe studied the prebiotic activity of EPSs from 5 Lactobacillus plantarum strains using an in vitro gut microbiota model. The EPS with the strongest activity was fed to DSS-induced IBD mice. We then examined the mice's gut microbiota, serum cytokines, oxidative stress, and metabolic conditions. ResultsIn the in vitro experiment, Only EPS32 of the 5 EPSs exhibited a good prebiotic activity similar to inulin. The EPS32 is composed of rhamnose, fructose, and galactose in a ratio of 8.2:1:1.7. When feeding mice with 50 mg/kgBW/day EPS32 for 10 days, it significantly alleviated the IBD symptoms including restoring gut microbiota dysbiosis, increasing short-chain fatty acid production, lowering pro-inflammatory cytokine levels, lowering oxidative stress in the lumen, and restore the metabolic conditions. ConclusionContinuous intake of prebiotic EPS can effectively alleviate IBD symptoms.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
