Abstract
In this paper, a novel molecularly imprinted polymer (MIP) electrochemical sensor for selective detection of an antidepressant drug, sertraline (STR) has been developed. The precipitation polymerization method in the presence of sertraline hydrochloride as template molecules was used for synthesize of MIP nanoparticles. The sensor was developed by embedding a very thin layer of the MIP/graphene suspension on the handmade screen-printed carbon electrodes (SPCEs). The K3 [Fe(CN)6]/K4[Fe(CN) 6] redox couple was used as a probe to characterize the sensor by using cyclic voltammetry & differential pulse voltammetry methods. The sertraline binding experiments indicated that the MIP/graphene modified SPCEs have higher adsorption ability than the non-imprinted polymer(NIP)/graphene modified SPCEs. Factors affecting the sensor response such as composition of MIP/graphene suspension, extraction pH, preconcentration time and stirring rate of sample solution were optimized. Under optimal conditions, the sensor exhibited good sensitivity (177.25 µA L µmol−1) for sertraline with a linear range of 5.0 × 10−9 to 7.5 × 10−7 M (R2 = 0.9971) and detection limit of 1.99 × 10−9 M. The sensor was successfully applied for the determination of sertraline in tablet and human serum samples with recovery values in the range of 97.98–101.33%.
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