Abstract

The traditional systems of treatment such as Ayurveda, Unani, and Siddha, western herbal medicine, traditional Chinese medicine and homeopathy use herbs for the treatment. Many researchers has prescribed about the importance of herbal medicine in the treatment of various diseases and because of the accessibility and cost effectiveness herbal treatment is still in practice by large number of practitioners. Luffa cylindrica Linn. (Curcubitaceace ) fruits was reported to possess a number of medicinal properties including used as immunostimulant, anti-inflammatory, anti-tumour, antibacterial, antifungal and anti-viral activities and also induce uterine contraction to hasten child birth (Oxytocics). The present study was investigated the anti-ulcer activity of hydroalcoholic extracts of fruits of luffa cylindrica Linn by using aspirin plus pylorus ligated model at the dose of 100 and 200 mg/kg. The results were showed significantly (p<0.01) decreased in ulcer index (1.31±0.33) and gastric volume (2.18±0.74) when compared with control (3.92±0.27) and 95.85±0.12) respectively at the dose of 200 m/kg and also showed significant effect when compared with omeprazole (standard) at 2mg/kg. In this study concluded that the hydroalcoholic extract of fruit of luffa cylindrica act as anti-ulcer activity due to presence of alkaloids and flavonoids.

Highlights

  • Gastric ulcer is a lesion caused by increased oxidative stress, neutrophil infiltration and decrease in blood flow, necrosis and inflammation (Silva et al, 2013)

  • Focus on plant research has increased worldwide and several studies had showed immense potential of medicinal plants. (Dahanurkar et al, 2000) Herbal medicines derived from plant extract, are increasingly being recognized in treating various clinical diseases, with relatively little knowledge of their modes of action. (Begum et al, 2008) Luffa cylindrica (L.) fruit is commonly called sponge gourd, loofa, vegetable sponge, bath sponge or dish cloth gourd, is a member of cucurbitaceous family

  • The aim of the study was to investigate the effectiveness of healing activity of hydroalcoholic extracts of fruits of luffa cylindrica Linn by using aspirin plus pylorus ligated model

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Summary

Introduction

Gastric ulcer is a lesion caused by increased oxidative stress, neutrophil infiltration and decrease in blood flow, necrosis and inflammation (Silva et al, 2013). Side effects such as osteoporosis, hypergastrinemia and hyperplasia of enterochromaffinlike cells (ECL) are common in the prolonged therapy with antisecretory drugs. Focus on plant research has increased worldwide and several studies had showed immense potential of medicinal plants. In view of the above, the search for new antiulcer treatments is essential, focusing mainly on the search for agents that promote effective healing of gastric ulcer. The present study was carried out using the aspirin plus pylorus ligated experimental model. The aim of the study was to investigate the effectiveness of healing activity of hydroalcoholic extracts of fruits of luffa cylindrica Linn by using aspirin plus pylorus ligated model

Materials and Methods
Results and Discussion
Conclusion
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